Changes of lymphocyte subsets in smear-negative pulmonary tuberculosis
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Date
2023-06
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer - Medknow
Abstract
Background and Aims: The host immune system plays an important role in the pathogenesis and defense mechanism of Mycobacterium tuberculosis (Mtb). This study aimed to explore the different changes in the immune system between smear-negative pulmonary tuberculosis (PTB) and smear-positive PTB patients. Materials and Methods: A total of 85 active PTB patients and 50 healthy adults were enrolled. The participants were divided into smear-negative PTB, smear-positive PTB, and control groups. Chest computed tomography (CT) and lymphocyte subgroup counts in peripheral blood were measured in all participants. Results: There were higher numbers of CD4 + T-cells, NK cells, and pulmonary cavities in the smear-positive PTB group, whereas the numbers of B-ells were significantly increased in the smear-negative PTB group. Conclusions: Smear-negative PTB showed fewer pulmonary cavities, mild inflammatory response, lower numbers of immune cells, and higher numbers of B- cells.
Description
Keywords
Lymphocyte subsets, mycobacterium tuberculosis, pulmonary tuberculosis, smear-negative, smear-positive
Citation
Yang X, Feng H.. Changes of lymphocyte subsets in smear-negative pulmonary tuberculosis. Indian Journal of Pathology & Microbiology. 2023 Jun; 66(2): 321-326