Isolated pancreatic myeloid sarcoma: A potential mimicker of pancreatic adenocarcinoma

Myeloid sarcoma (MS) is an extramedullary proliferation of immature myeloid cells which may occur as a progression of myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), or myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) and as acute myeloid leukemia (AML) relapse. Rarely may it be de novo. Lymph nodes, skin, lungs, intestine are the commonly involved sites. However, an isolated pancreatic MS is seldom reported in the literature. Herein, we report one such case which was misdiagnosed as pancreatic adenocarcinoma on the clinico-radiological examination which misled us away from preoperative diagnostic sampling, and a Whipple pancreaticoduodenectomy was performed. Histopathological examination in conjunction with immunohistochemistry revealed the final diagnosis of isolated MS of the pancreas. We emphasize that although rare, a clinical suspicion along with preoperative histopathological examination may lead to early diagnosis, targeted management, and a better clinical outcome in such cases.

Keywords

Chloroma, granulocytic sarcoma, myeloid sarcoma, pancreatic malignancy

Citation

Soni A, Jindal S, Narang V, Singh A, Paul D, Kaur H.. Isolated pancreatic myeloid sarcoma: A potential mimicker of pancreatic adenocarcinoma. Indian Journal of Pathology & Microbiology. 2022 Sept; 65(3): 676-678

URI

https://imsear.searo.who.int/handle/123456789/223320

Collections

Indian Journal of Pathology & Microbiology

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