Budding yeast in a child with acute leukemia: Nothing CRYPT(O)IC about it
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Date
2022-06
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer - Medknow
Abstract
A 13-year-old girl child with B-cell precursor acute lymphoblastic leukemia presented with complaints of fever, fatigue and left-sided iliac mass of 20 days duration. Preliminary blood culture from the peripherally inserted central catheter (PICC) demonstrated the presence of budding yeast cells. This is a rare form of “Disseminated cryptococcosis”. Budding yeast cells emphasizes the significance of various differentials of yeast in positive blood cultures bottles, as identifying Cryptococcus from gram stain can be complicated. This manuscript also highlights the presence of crystalloid geometric appearance like “Buckminsterfullerene”, which is derived from the mucopolysaccharide capsule in Cryptococcus. These structures are rarely observed, and in this case, are exceptionally remarkable.
Description
Keywords
Childhood leukemia, Cryptococcus, MALDI-TOF
Citation
Kanaujia R, Ramanathan S, Sarode R, Kanaujia R, Rudramurthy SM, Gupta S.. Budding yeast in a child with acute leukemia: Nothing CRYPT(O)IC about it. Indian Journal of Pathology & Microbiology. 2022 Jun; 65(2): 468-471