Exacerbation of Erythema Nodosum Leprosum Possibly Triggered by COVID-19 Vaccine : A Case Repor
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Date
2022-09
Authors
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Publisher
Hind Kusht Nivaran Sangh (Indian Leprosy Association)
Abstract
Erythema nodosum leprosum (ENL) is an immune complex mediated type III hypersensitivity reaction seen in patients of borderline lepromatous and lepromatous leprosy. It can be caused by a wide array of triggers and can be seen before, during, or after completion of anti-leprosy therapy. There are multiple well-known triggers for type 2 reactions like the initiation of multidrug therapy, Mantoux testing, vaccination, mental and physical stress, and physiological states like pregnancy. Herein, we report a case of exacerbation of ENL in a middle-aged woman, probably due to COVID-19 vaccine while she was well-controlled on immunosuppressive therapy. The episode was treated with non-steroid anti-inflammatory drugs and oral steroids and the symptoms resolved within 2 weeks. Although causality was highly possible between the occurrence of ENL and COVID-19 vaccine, physicians should be aware that it can be easily managed with proper care and medicines and this should not be a basis for deferring the vaccine.
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Keywords
Erythema Nodosum Leprosum, AstraZeneca-Oxford, COVID-19 Vaccine, Leprosy, Vaccination, Type 2 Reaction
Citation
Gupta S, Narang T, Chhabra S, Dogra S. Exacerbation of Erythema Nodosum Leprosum Possibly Triggered by COVID-19 Vaccine : A Case Repor. Indian Journal of Leprosy. 2022 Sep; 94: 275-278