Human papillomavirus and head and neck squamous cell carcinoma in a UK population: Is there an association?
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Date
2022-03
Journal Title
Journal ISSN
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Publisher
Wolters Kluwer - Medknow
Abstract
Background: Human papillomavirus (HPV) is an evolving important risk factor for head and neck cancer (HNC) especially for individuals who do not smoke and drink alcohol. The aim of this study was to establish the prevalence of HPV infection and elucidate its association with head and neck squamous cell carcinoma (HNSCC) patients in UK population. Methods: The presence and association of HPV was investigated in HNSCC patients in this retrospective clinical study. Samples were obtained from archived biopsies and resections. HPV screening was performed by the use of polymerase chain reaction (PCR) using the GP5+/GP6+ and the SPF1/2 consensus as primers and by immunohistochemistry (IHC). Samples of viral warts that were IHC positive for HPV and fibroepethelial polyps (FEP) were used as positive and negative controls respectively. Results: The cohort included 124 patients with HNSCC with an age range of 27–97 years (median 60 years) and a male to female ratio of 2:1. Among the 124 HNSCC 43/124 (34.7%) were from the tongue 74/124 (60%) presented with advanced stage III or IV disease 112/124 (90%) had a conventional phenotype 84/124 (68%) were moderately differentiated and 89/124 (72%) had bands or cords at the invasive front. Of the 124 patients with HNSCC 84/124 (68%) demonstrated the presence of HPV 0/124 (0%) was for oral squamous cell carcinomas (OSCC). HPV16 was the associated virus type in all positive samples. However no significant association was observed between HPV positivity and other clinico-pathological variables including age and gender of the patients stage and malignancy differentiation. Conclusion: The results we provide suggest that HPV infection is low in HNSCC in general and absent in OSCC specifically in this UK population during this time period. This implies that HPV infection may not play an important role in HNSCC carcinogenesis compared to other risk factors in UK population. This information can aid in more effective treatment approaches for treating UK cases of HNSCC.
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Keywords
Carcinogenesis, head and neck neoplasms, mouth neoplasms, papillomaviridae, risk factors, squamous cell carcinoma of head and neck, United Kingdom
Citation
Al?Dabbagh Raghad, Al?Hazmi Nadia, Alhazzazi Turki Y, Barrett AW, Speight Paul M. Human papillomavirus and head and neck squamous cell carcinoma in a UK population: Is there an association?. Indian Journal of Cancer . 2022 Mar; 59(1): 65-72