Evaluation of cyclosporine-A obtained from Tolypocladium sp. for immunosuppressive potential.

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Date
1991-08-01
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Abstract
Cyclosporine-A obtained from an indigenous isolate of Tolypocladium sp. was evaluated for immunosuppressive potential by skin grafting in rats using the commercially available Sandimmune as reference at 15 and 30 mg/kg/day for a period of 14 days. The Sandimmune treated animal group showed 83 per cent acceptance of skin grafts while the test preparation treated group showed 67-83 per cent acceptance. The degree of nephro- and hepatotoxicity was comparable for both the preparations.
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Balaraman K, Kuppusamy M, George N, Anandkumar K, Sekar C. Evaluation of cyclosporine-A obtained from Tolypocladium sp. for immunosuppressive potential. Indian Journal of Medical Research. 1991 Aug; 94(): 304-6
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https://imsear.searo.who.int/handle/123456789/21689
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Indian Journal of Medical Research