Study of Effectiveness of Convalescent Plasma-therapy in Moderate to Severely ill COVID-19 Patients

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JIMA2023v121n2p33.pdf (140.44 KB)
Date
2023-02
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Indian Medical Association
Abstract
Background : Convalescent Plasma-therapy, a classic adaptive immunotherapy used in the treatment of SARS, MERS and 2009 H1N1 pandemic with acceptable efficacy and safety in the past. Convalescent Plasma-therapy was taken into consideration in management of COVID-19 disease during the initial days of pandemic but was withdrawn later due to its doubtful beneficial role. This study aims to explore the beneficial role of Convalescent plasma and to determine whether Convalescent Plasma-therapy holds a second chance in treating SARS-CoV-2. Methods : This cross-sectional observational study includes 82 cases of moderate to severely ill COVID-19 patients who received Convalescent Plasma-therapy and 41 controls who didnꊰ. regular monitoring of Total Leukocyte Count (TLC), PaO2/FiO2 (PaO2 is partial pressure of Oxygen in arterial blood, fractional inspired oxygen (P/F ratio), Neutrophil to Lymphocyte Ratio (N/L ratio) inflammatory markers, respiratory rate, oxygen saturation, ABG and Radiological Imaging was done for comparative analysis. Results : In case group 39 patients (47.56%) were on oxygen mask, 17 patients (20.73%) on Non-invasive Ventilation (NIV), 9 Patients on Non-rebrether Mask (NRM) (10.97%), 16 patients (19.51%) on room air, 1(1.21%) on High Flow Nasal Cannula (HFNC) initially. After 7th day of Convalescent Plasma-therapy 49 patients (59.75%) were on room air which suggests significant improvement in mode of ventilation in case group as compared to Control Group. Mean respiratory rate in case group was 30.46 Cycles Per Minute (CPM) initially and 24.7 CPM on day 7th of Plasma-therapy which is statically significant. Conclusion : Plasma-therapy is effective if given in early stage of disease and Convalescent Plasma donors having adequate antibody titre.
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Convalescent plasma-therapy, COVID-19, P/F ratio, Mode of ventilation
Citation
Saluja Manoj, Sharma Prakarsh, Sharma Sidharth, Chittora Saurabh, Meena Deelip, Bhargava Gaurav. Study of Effectiveness of Convalescent Plasma-therapy in Moderate to Severely ill COVID-19 Patients. Journal of The Indian Medical Association. 2023 Feb; 121(2): 33-37
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https://imsear.searo.who.int/handle/123456789/216686
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Journal of the Indian Medical Association