Disulfiram Induced Mania — A Case Report
Loading...
Date
2022-05
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Medical Association
Abstract
Disulfiram has been most widely used in patients suffering from alcohol dependence. When taken along with alcohol it can cause various side effects like flushing, drowsiness, rashes, hyperventilation, palpitations etc. Mania due to Disulfiram is an uncommon side effect and there are only a few reports of it. We hereby report a case of the development of Mania in an individual with alcohol dependence following 2 months of treatment with a therapeutic dose of Disulfiram. Before the onset of mania, the patient was abstinent from alcohol for about 2 months, which made substance-induced mania unlikely. The possible mechanism for this is the dopamine hypothesis which suggests that Disulfiram inhibits dopamine-Beta-hydroxylase which is responsible for the conversion of dopamine to Nor-adrenaline and increases the dopamine level which is responsible for psychotic and mania symptoms. This possibility of Disulfiram induced mania should be assessed whenever clinicians encounter patients with dual diagnosis, as this might change the management as such.
Description
Keywords
Adverse effect, Disulfiram, Mania
Citation
Spoorthy Mamidipalli Sai, Gupta Parul. Disulfiram Induced Mania — A Case Report. Journal of The Indian Medical Association. 2022 May; 120(5): 59-61