Angiotensin Receptor-Neprilysin Inhibitor Therapy and Cardiac Remodeling in Heart Failure: Consensus Statement from India

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JAPI2023v71n4p73.pdf (1.02 MB)
Date
2023-04
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Association of Physicians of India
Abstract
Adverse cardiac remodeling refers to progressive structural and functional modifications in the heart because of increased wall stress in the myocardium, loss of viable myocardium, and neurohormonal stimulation. The guideline-directed medical therapy for Heart failure (HF) includes Angiotensin receptor-neprilysin inhibitor (ARNI) (sacubitril/valsartan), ?-blockers, sodium-glucose co-transporter 2 (SGLT2) inhibitors, and mineralocorticoid receptor antagonists (MRA). ARNI is under-prescribed in India despite its attractive safety and efficacy profile. Therefore, the consensus discusses objectives and topics related to ARNI in the management of cardiac remodeling, and experts shared their views on the early timely intervention of effective dosage of ARNI to improve the diagnosis and enhance mortality and morbidity benefits in cardiac reverse remodeling (CRR).
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Chopra H K, Wander G S, Nair Tiny, Ponde C K, Nanda Navin C, Narula Jagat, Ray Saumitra, Venugopal K, Iyengar S S, Kasliwal R R, Chandra Praveen, Prakash Sunil, Bansal Sandeep, Rana D S, Kerkar Prafulla, Dasbiswas Arup, Sawhney JPS, Shanmungasundram S, Kumar Viveka, Vijayalakshmi I B,Pancholia A K, Sharma Vinod, Kapoor Aditya, Swami Onkar C, Isser H S, Rastogi Vishal, Arora Y K, Omar Ashok K, Sathe Sunil, Rajput Rajeeve, Prabhakar D, Paul G Justin, Jagia Priya, Malhotra Poonam, Suryaprakash G, Mittal Vinod, Jagia Manish, Jabir A, Mishra S S, Routray S N, Sinha Ajay Kumar, Bhargava Mohan, Mahmood Kiran, Lal Shreya, Dabhade Dhammdeep, Bhatia Mona, Kalra Pramila, Katyal V K, Tandon Rohit, Grover Rahul, Chhabra Abhinav, Shastry N R. Angiotensin Receptor-Neprilysin Inhibitor Therapy and Cardiac Remodeling in Heart Failure: Consensus Statement from India. Journal of the Association of Physicians of India. 2023 Apr; 71(4): 73-82
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https://imsear.searo.who.int/handle/123456789/216388
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Journal of the Association of Physicians of India