Hematological Changes and Antidiabetic Activities of Colocasia esculenta (L.) Schatt Stem Tuber Aqueous Extract in Alloxan Induced Diabetic Rats
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Date
2020-06
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SCIENCEDOMAIN international
Abstract
Managementofbloodglucoselevelisthehallmarkinthetreatmentofdiabetes.MuchworkhasnotbeendoneonthemanagementofdiabetesusingthestemtuberextractofColocasiaesculenta.TheobjectiveofthisstudywastoevaluatetheantihyperglycemicandhematologicalparameteronColocasiaesculentaaqueousstemextractinalloxaninduceddiabeticrats.Sixty(60)maleratswereusedinthestudy.Sevendaysofacclimatization,theratsweredividedrandomlyintosixgroupsoffiveineachgroup.Group1:Servedasnormalcontrol,Group2:Diabeticcontrolgroup(negativecontrol),Group3:Diabeticgroupand“Glucinorm-M80”(positivecontrol),Group4:Diabeticgroupandextractat200mg/kgbodyweight,Group5:Diabeticgroupandextractat400mg/kg,Group6:Diabeticgroupandextractat600mg/kg.Diabeteswasinducedinalbinoratsby intraperitonealinjectionofalloxanatasingledoseof120mg/kgbodyweightingroups2to6afterstarvingthemfor24hrs.Theanimalsweregivenfeedandwateradlibitum.ThealbinoratswereadministeredfortwentyeightdayswiththeaqueousColocasiaesculentastemtuber,afterwhichtheywerefastedovernight,anaesthetizedwithchloroformandsacrificed.Theresultshowedthattherewasasignificantincrease(p<0.05)inmeanbodyweightofthepositivecontrolandthetreatmentgroups(200mg/kgto600mg/kg)whencomparedwiththenegativecontrolwhichhasasignificantdecrease(p<0.05)inmeanbodyweight.Theresultalsoshowedasignificantincrease(P<0.05)intheconcentrationsofRBC,PCV,HB,whilePLTandMCHshowedsignificantdecrease(P<0.05)inthetreatmentgroupsandnegativecontrolgroupwhencomparedwiththenormalcontrolgroup.Alsotherewasanosignificant(P<0.05)differenceinMCHCofthetreatmentgroupswhencomparedwiththecontrolgroupandnegativecontrolgroup.Alsotherewasasignificantdifferenceinglycosylatehemoglobinofthetreatmentgroupswhencomparedwiththecontrolgroupandnegativegroup.ThisstudyhasdemonstratedthataqueousstemtuberextractofColocasiaesculentahasasignificantincreaseonbodyweightwhichmayhavearoleofimprovingthestatesofpossibleweightlossfollowingcomplicateddiabetes.Also,aqueousstemtuberextractofColocasiaesculentahasanameliorativeeffectonsugarlevelandsomehematologicalparametersofalloxaninduceddiabeticratsshowingeffectivediabeticcontrolandmanagementofdiabetes
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Keywords
Colocaciaesculenta, hematological, antihyperglycemic, diabetes, alloxan
Citation
Nwaogwugwu, Caleb Joel, Uhegbu, F. O., Okereke, S. C., Nosiri, C. I., Amaka, E. N., Nwamaka Idume Joy. Hematological Changes and Antidiabetic Activities of Colocasia esculenta (L.) Schatt Stem Tuber Aqueous Extract in Alloxan Induced Diabetic Rats. Journal of Pharmaceutical Research International. 2020 Jun; 32(10): 1-9