Serum Procalcitonin as a Biomarker in Complicated Appendicitis -A Cross Sectional Study.
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Date
2020-07
Journal Title
Journal ISSN
Volume Title
Publisher
Akshantala Enterprises Private Limited
Abstract
Early diagnosis and treatment of acute appendicitis prevents development of markers that have been used to improve the diagnostic accuracy in appendicitis. The objective of this study was to assess the role of procalcitonin in the prediction of complications of appendicitis. METHODSA cross sectional study involving 110 patients diagnosed with acute appendicitis was conducted. After obtaining ethical clearance, informed written consent was obtained from the patients. Blood investigations such as total leucocyte counts, C reactive proteins and procalcitonin levels were done. Cases were categorized into uncomplicated appendicitis (n=67) and complicated appendicitis (n=43). Descriptive analysis, ROC analysis of predictive validity, and Shapiro Wilk test comparing all the three parameters in both the groups was done using IBM SPSS version 22. RESULTSThe mean age was 29.59 ± 9.17 years. 67 (60.91%) had uncomplicated appendicitis and 43 (39.09%) had complicated appendicitis. The WBC, hsCRP, serum procalcitonin percentile had good predictive validity in predicting score as indicated by the area under the curve (0.822). Serum procalcitonin value had a sensitivity of 97.67% in predicting the type of appendicitis and specificity of 94.03%. CONCLUSIONSSerum procalcitonin is a better biomarker than total leucocyte count and hs-C reactive protein in predicting complications of appendicitis and differentiating it from uncomplicated appendicitis.
Description
Keywords
Procalcitonin, Predictor, Complicated Appendicitis
Citation
Nadipanna Sreeramulu Patrapalli, Nagaraj Shashidhar Kurpad, Anand Varsha. Serum Procalcitonin as a Biomarker in Complicated Appendicitis -A Cross Sectional Study.. Journal of Evolution of Medical and Dental Sciences. 2020 Jul; 9(30): 2129-2132