Exfoliation Technique of Composing and Depictions of Clopidogrel Bisulphate Afloat Microspheres

Gastro retention dosage forms are obligatory for holding the drug in the stomach for area definite drug discharge by afloat technique. Floating microspheres (FM) of Clopidogrel Bisulphate (CB) were fabricated to increase the drug’s reach to blood and to show elongated drug release.METHODSFM of CB were prepared by the ion gelation (exfoliation) method using ethyl cellulose, carrageenan gum, and sodium alginate. The drug-loaded FM were designed and assessed for their physicochemical characteristics including drug-excipient friendly behaviour by Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-Red (FTIR).RESULTSThe DSC and FTIR study revealed the compatibility of CB with the excipients used. The percentage yield of FM from all formulations was good and showed satisfactory buoyancy and floating time. % CB release for the formulations was found up to 98.5% (F8) till 10th hour. The release kinetics revealed that CB discharge from the devices was best fitted to Hixson Crowell’s model with regression values ranging from 0.887 to 0.989.CONCLUSIONSFM with CB can be formulated using sodium alginate, ethyl cellulose and carrageenan gum by exfoliation gelation method.

Keywords

Clopidogrel Bisulphate, Carrageenan, Buoyancy, Discharge

Citation

Harsha wamygari Satya, Ahad Hindustan Abdul, Haranath Chinthaginjala, Dasari Rahul Raghav, Gowthami Madana, Varam Naga Jyothi, Bitranganti Samhitha Rao, Musa Gamaa Birir Mohamed. Exfoliation Technique of Composing and Depictions of Clopidogrel Bisulphate Afloat Microspheres. Journal of Evolution of Medical and Dental Sciences. 2020 Apr; 9(14): 1156-1160

URI

https://imsear.searo.who.int/handle/123456789/214806

Collections

Journal of Evolution of Medical and Dental Sciences

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