Factors influencing the gut microbiome in children: from infancy to childhood
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Date
2019-06
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Sciences
Abstract
The human microbiota plays a crucial role in educating the immune system and influencing host health right since birth.Various maternal factors along with the vertical microbial transfer from the mother, as well as the horizontal environmentaltransmission and internal factors relating to the infant, play a crucial role in modulating the gut microbiota. The early lifemicroflora is highly unstable and undergoes dynamic changes during the first few years, converging towards a morestabilized adult microbiota by co-evolving with the host by the age of 3–4 years. Microbiota studies have underlined therole of dysbiosis in developing several metabolic disorders like obesity, diabetes and immune-related disorders like asthma,to name a few. Thus, understanding early life microbial composition and various factors affecting the microbial communitywill provide a platform for developing strategies/techniques to maintain host health by restoring gut microbial flora. Thisreview focuses on the factors that affect the microbial composition of the foetus in utero, during birth, infancy throughchildhood.
Description
Keywords
Birth mode, infants, maternal health, microbiome
Citation
Kumbhare Shreyas V, Patangia Dhrati V, Shouche Ravindra H Patil Yogesh S, Patil Nitinkumar P. Factors influencing the gut microbiome in children: from infancy to childhood. Journal of Biosciences. 2019 Jun; 44(2): 1-19