Histone H2A isoforms: Potential implications in epigenome plasticity and diseases in eukaryotes
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Date
2020-01
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Sciences
Abstract
Epigenetic mechanisms including the post-translational modifications of histones, incorporation of histonevariants and DNA methylation have been suggested to play an important role in genome plasticity by allowingthe cellular environment to define gene expression and the phenotype of an organism. Studies over the pastdecade have elucidated how these epigenetic mechanisms are significant in orchestrating various biologicalprocesses and contribute to different pathophysiological states. However, the role of histone isoforms and theirimpact on different phenotypes and physiological processes associated with diseases are not fully clear. Thisreview is focussed on the recent advances in our understanding of the complexity of eukaryotic H2A isoformsand their roles in defining nucleosome organization. We elaborate on their potential roles in genomic complexity and regulation of gene expression, and thereby on their overall contribution towards cellular phenotypeand development of diseases
Description
Keywords
Cancer, chromatin organization, histone isoforms, pathophysiology
Citation
Shah Sanket, Verma Tripti, Rashid Mudasir, Gadewal Nikhil, Gupta Sanjay. Histone H2A isoforms: Potential implications in epigenome plasticity and diseases in eukaryotes. Journal of Biosciences. 2020 Jan; : 1-11