PSCRIdb: A database of regulatory interactions and networks of pluripotent stem cell lines
Date
2020-03
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Sciences
Abstract
Pluripotency in stem cells is regulated by a complex network between the transcription factors, signalingmolecules, mRNAs, and epigenetic regulators like non-coding RNAs. Different pluripotent stem cell (PSC)lines were isolated and characterized to study the regulatory network topology to understand the mechanismthat control developmental potential of pluripotent cells. PSCRIdb is a manually curated database of regulatoryinteractions including protein–protein, protein–DNA, gene–gene, and miRNA–mRNA interactions in mouseand human pluripotent stem cells including embryonic stem cells and embryonic carcinoma cells. At present,22 different mouse and human pluripotent stem-cell-line-specific regulatory interactions are compiled in thedatabase. Detailed information of the four types of interaction data are presented in tabular format andgraphical network view in Cytoscape layout. The database is available at https://bicresources.jcbose.ac.in/ssaha4/pscridb. The database contains 3037 entries of experimentally validated molecular interactions that canbe useful for systematic study of pluripotency integrating multi-omics data. In summary, the database can be auseful resource for identification of regulatory networks present in different pluripotent stem cell lines.
Description
Keywords
Cytoscape, Graphical, multi-omics, network, regulatory interactions, systematic
Citation
Banerjee Krishnendu, Jana Tanmoy, Ghosh Zhumur, Saha Sudipto. PSCRIdb: A database of regulatory interactions and networks of pluripotent stem cell lines. Journal of Biosciences. 2020 Mar; : 1-8