Naturally occurring anti-native DNA antibodies in SLE binding Z-DNA.
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1990-06-01
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Abstract
A high degree of specificity of circulating anti-DNA antibody for double stranded DNA in the sera of SLE patients was found, as compared to single stranded polymer. The antibody recognized brominated DNA, a polymer that appears to attain Z-conformation as indicated on the basis of UV absorption characteristics. The existence in native DNA of regions undergoing B----Z transition has been detected.
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Sehgal V, Ali R. Naturally occurring anti-native DNA antibodies in SLE binding Z-DNA. Indian Journal of Medical Research. 1990 Jun; 92(): 158-62