Extra-abdominal aggressive fibromatosis treated with meloxicam and sorafenib: An encouraging option
Loading...
Date
2020-09
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer India Pvt. Ltd.
Abstract
Objective: Aggressive fibromatosis (AF), also called desmoid tumor, is an uncommon soft-tissue neoplasm. Characteristically, it expands locally without metastatic potential. However, its tendency of relapse after curative resections has been well documented. Effective treatment options have been limited and there is a clear need for novel treatment strategies. Methods: We used combination therapy including multikinase tyrosine kinase inhibitor for treating AF. Results: We presented a case of an extra-abdominal AF who was successfully treated with meloxicam and sorafenib combination in our clinic. She tolerated this therapy well with only mild side effects. To our knowledge, this is the first case report of an extra-abdominal AF with a major partial response to sorafenib and meloxicam combination. Conclusion: Due to the favorable toxicity profile of sorafenib and meloxicam, this combination might be an effective treatment option for patients with locally aggressive and inoperable AF.
Description
Keywords
Aggressive fibromatosis, meloxicam, oral tyrosine kinase inhibitor, sorafenib
Citation
Sari Murat. Extra-abdominal aggressive fibromatosis treated with meloxicam and sorafenib: An encouraging option. Journal of Cancer Research and Therapeutics. 2020 Sep; 16(4): 900-902