Thiol-disulfide homeostasis in breast cancer patients
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Date
2019-10
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer India Pvt. Ltd.
Abstract
Objective: The aim of our study is to assess thiol-disulfide homeostasis (TDH), which is a biomarker of systemic oxidative stress, in breast cancer patients. Materials and Methods: Thirty-seven breast cancer patients and 31 age-matched healthy volunteers were enrolled in this study. Serum native thiol, disulfide, and total thiol levels and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were analyzed using a novel colorimetric method. Results: Serum native thiol level was statistically significantly lower in breast cancer patients (350.39 ± 7.15) than in healthy controls (380.60 ± 7.35) (P = 0.008). Serum disulfide level was statistically significantly higher in breast cancer patients (24.96 ± 0.85) than in healthy controls (19.25 ± 1.34) (P = 0.002). Conclusion: To our knowledge, this study is the first study in the literature that investigated TDH in breast cancer patients. We have concluded that an alteration in TDH due to oxidative stress is likely to have a role in the pathogenesis of breast cancer
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Keywords
Breast cancer, oxidative stress, thiol‑disulfide homeostasis
Citation
Eryilmaz Mehmet Ali, Kozanhan Betül, Solak Ibrahim, Çetinkaya Çigdem Damla, Neselioglu Salim, Erel Özcan. Thiol-disulfide homeostasis in breast cancer patients. Journal of Cancer Research and Therapeutics. 2019 Oct; 15(5): 1062-1066