A study on patients with coronary artery disease with special reference to bone mineral density
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Date
2020-07
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Background: Osteoporosis and Coronary artery disease are known to share common risk factors, like inflammation, but a direct relationship between the two has not been established. Some of the previous studies showed low BMD (osteoporosis and/orosteopenia) as an independent predictive factor for coronary artery disease in ambulatory patients. However, some reports have failed to demonstrate a direct relationship between low bone mineral density (BMD) and CAD or cardiovascular risk factors. This study was carried out to estimate bone mineral density (BMD) in patients with coronary artery disease (CAD) and also to evaluate the association between bone mineral density and coronary artery disease.Methods: Hospital based prospective observational study, involving 96 consecutive patients who were referred for coronary angiography for the evaluation of established or suspected CAD and also patients who had acute coronary syndrome (ACS) are enrolled in this study. BMD was determined for the lumbar spine (L2-L4) and femoral neck using DXA scan.Results: The total number of subjects was 96. Out of 96, 24 (25%) patients were females and remaining 72 (75%) were males. Coronary angiography was carried out in all patients. 42 patients from the total had coronary angiography proven single vessel disease (SVD), 33 patients had double vessel disease (DVD) and 21 patients had triple vessel disease (TVD). DXA scan was carried out in all patients. T- score of neck of femur region and lumbar spine was calculated. Neither the presence of significant coronary stenoses ≥50% in two or more coronary vessels nor the prevalence of severe coronary stenoses ≥70% differed significantly between patients with normal bone density, osteopenia, or osteoporosis (p<0.05, respectively).Conclusions: The result of this study suggests that in patients undergoing coronary angiography for the evaluation of CAD, the prevalence of low BMD is high; however, there is no statistically significant relationship between osteoporosis, osteopenia and coronary artery disease state.
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Keywords
Coronary artery disease, DXA scan, Osteoporosis, Osteopenia
Citation
Ete Tony, Khan Shakeel Ahamad, Wankhar Baphira, Pala Star, Malviya Amit, Mobing Habung, Naku Narang, Bamon Amethyst, Kumar Utpal, Kumar Arun, Fanai Vanlalmalsawmdawngliana, Pohlong Stephenson, Mishra Animesh. A study on patients with coronary artery disease with special reference to bone mineral density. International Journal of Research in Medical Sciences. 2020 Jul; 8(7): 2395-2399