Clinical and radiological features of fahr’s disease: a mimicker of varied neurological manifestations
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Date
2020-06
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Fahr’s disease is a disorder characterized clinically by a wide spectrum of varied clinical-neurological and psychiatric manifestations occurring secondary to intracranial calcifications with subsequent neuronal cell loss. Though the disease can present in early childhood or adolescence the usual age of manifestation is around 4th-5th decades of life. We report a series of 6 Fahr’s disease cases with respect to different clinical and radiological manifestations. The details of different clinical manifestations with respect to the disease were studied. The frequency of symptoms, the radiological pattern of intracranial calcifications and the association of different parameters were studied. Progressive cognitive decline and Parkinsonism was detected in all the patients but in none of them it was the chief presenting feature. Seizure was presenting symptoms in 3 patients. Chorea was encountered in 2 patients as the presenting complaint. Mild wide-based cerebellar ataxic gait was found in only one patient but other cerebellar signs were absent. Athetosis, dyskinesia, or dystonia was present in none of our patient. CT scan revealed symmetric basal nuclei and cerebellar calcification in all patients. The disease needs a high index of suspicion and CT brain scanning should always be performed in patients younger than 50 years who present with refractory seizures, Parkinsonism and cognitive decline. However radiological findings did not predict the presentation and outcome.
Description
Keywords
Computerized tomography, Fahr’s disease, Intracranial calcifications, Parkinsonism
Citation
Mohapatra Suvendu Kumar, Nayak Rashmita Binod. Clinical and radiological features of fahr’s disease: a mimicker of varied neurological manifestations. International Journal of Research in Medical Sciences. 2020 May; 8(5): 2297-2302