Evaluation of serum sex hormones and CD4+ count among HIV patients on HAART, HAART naive patients and apparently healthy subjects in Sokoto, Nigeria
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Date
2020-03
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Background: Acquired Immunodeficiency Syndrome (AIDS) is a chronic disease associated with Human Immunodeficiency Virus (HIV) which progressively induces depletion of CD4+ T cells, and increased vulnerability to opportunistic infections. Previous reported studies associated HIV-infected men with sexual dysfunction; hypogonadism is the most common endocrinological disorders. Its prevalence remains poorly defined and widely ranging from different studies.Methods: This study evaluated a total of 135 serum sex hormones (testosterone, estrogen, follicle stimulating hormone and luteinizing hormone) and its correlation with CD4+ counts among HIV patients on HAART, HAART naïve patients and negative control subjects (n=45). CD4+ cell counts were estimated using standard flow cytometry method and serum sex hormones by competitive enzyme immunoassay technique.Results: There were significantly lower testosterone and CD4+ levels (p<0.05) among HIV positive HAART naïve men compared to negative control. LH and FSH indicated significant increased (p<0.05) among HIV positive men on HAART.Conclusions: Antiretroviral therapy improves sexual functions in males infected with human immunodeficiency virus. Hence, further study to evaluate its effects on other sexual behaviors.
Description
Keywords
Acquired Immunodeficiency syndrome, Antiretroviral therapy, Antiretroviral naïve patients, Sex hormones
Citation
Yelwa Armiya’u Ahmed, Mainasara Abdallah Suleiman, Akuyam Shehu Abubakar, Adamu Balarabe Isah, Umar Zayyanu Usman, Abubakar Sharafudeen Dahiru, Muhammad Yahaya, Gamde Solomon Matthias, Abdulazziz Aisha. Evaluation of serum sex hormones and CD4+ count among HIV patients on HAART, HAART naive patients and apparently healthy subjects in Sokoto, Nigeria. International Journal of Research in Medical Sciences. 2020 Mar; 8(3): 891-895