Clinical, hematological and cytogenetic profile in fibroblast growth factor receptor 1 rearranged hematoloymphoid malignancies
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Date
2020-04
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
The background of this study is FGFR1 belongs to a family of four, high-affinity receptor tyrosine kinase and is a legitimate oncogene associated with uterine, cervical, prostate, bladder, colorectal and lung cancers. It is rarely concomitant in myeloid and lymphoid neoplasms but has an aggressive clinical course with a high mortality rate when present. Cytogenetic abnormalities involving the FGFR1 gene is most frequently observed in AML, MPN with eosinophilia, T-ALL and T-LBL with ZMYM2 gene being the most common fusion partner. Methods of this study was to authors report a series of 4 cases with FGFR1 rearrangements. Results is three patients presented as T-cell Lymphoblastic lymphoma (T-LBL) and one as mixed phenotype acute leukemia (MPAL). The T-LBL cases harboured the FGFR1/ ZMYM2 fusion and the MPAL case harbored the CNTRL/FGFR1 fusion as identified by conventional cytogenetics and confirmed by molecular studies. Conclusion is authors herewith describe the clinical, biochemical, molecular and cytogenetic features observed in these cases.
Description
Keywords
CNTRL gene codes for the protein centriolin, Fibroblast growth factor receptor 1, Mixed phenotype acute leukemia, T-lymphoblastic lymphoma, Zinc ginger MYM-type protein 2
Citation
Shetty Dhanlaxmi, Talker Elizabeth, Mohanty Purvi, Jain Hemani, Yadav Anil Kumar, Jain Hasmukh, Nayak Lingaraj, Tembare Prashant, Patkar Nikhil, Subramanian P. G., Kumar Amit. Clinical, hematological and cytogenetic profile in fibroblast growth factor receptor 1 rearranged hematoloymphoid malignancies. International Journal of Research in Medical Sciences. 2020 Apr; 8(4): 1556-1563