Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis
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Date
2019-09
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Background: To determine the prevalence of primary drug resistance to either rifampicin or isoniazid alone or both in newly diagnosed sputum smear positive pulmonary tuberculosis patients.Method: A prospective study 100 newly diagnosed sputum smear positive pulmonary TB patients was conducted. The patients with an age of ≥15 years and who had either not taken anti TB treatment or who had taken ATT for less than 1 month were enrolled in this study. Two sputum samples (5ml each), including one early morning sample as per the RNTCP guidelines were collected and subjected to line probe assay (LPA).Results: Out of 100 cases 6 were having resistance to both rifampicin and isoniazid, 9 has resistance to INH alone and 1 had resistance to rifampicin alone.Conclusion: The prevalence of primary drug resistance is high. For early and rapid detection of DR-TB newer modality should be used for the detection of primary drug resistance in sputum smear positive TB patients.
Description
Keywords
Multi-drug-resistant tuberculosis, Prevalence, Resistance
Citation
Kumar Ashok, Joshi Jawahar Lal, Umathoor Abdurazack, Chopra Vishal, Kaur Komaldeep, Mittal Vidhu. Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis. International Journal of Research in Medical Sciences. 2019 Sep; 7(9): 3532-3535