Green approach toward protection of secondary amine in pyrazole nucleus by PEG-400 and Boc catalyst
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Date
2020-05
Journal Title
Journal ISSN
Volume Title
Publisher
Open Science Publishers LLP
Abstract
The objective of the present study is the protection of secondary amine in the substituted pyrazole derivative withthe help of a green catalyst to facilitate the synthesis of anticancer compounds. Di-tert-butyl dicarbonate (Boc) hasbeen used as a protecting agent with various catalysts such as Polyethylene glycols-400, Dimethyl aminopyridine,and N, N-Diisopropyl ethylamine. In this study, five different synthetic methods have been applied, but success hasbeen achieved in only two. The very first method has been reported for the protection of secondary amine in pyrazole,associated with these catalysts. These synthetic methods had given a good yield and fewer side products, and it also agreen approach toward synthetic chemistry.
Description
Keywords
Di-tert-Butyloxycarbonyl, polyethylene glycol (PEG400), N,N-diisopropylethylamine, 4-dimethylamino pyridine.
Citation
Sharma Suman, Verma Amrita, Chauhan Rajani, Kulshrestha Rakhi. Green approach toward protection of secondary amine in pyrazole nucleus by PEG-400 and Boc catalyst. Journal of Applied Pharmaceutical Science. 2020 May; 2020 May: 054-062