Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India

Bauhinia foveolata Dalzell is an endemic tree, native to Southwest India (the Western Ghats). 13-Docosenamide wasisolated from ethyl acetate fraction, and quercetin (1), isorhamnetin (2), and odoratin-7-glucoside (3) were isolatedfrom butanol fraction of leaves. A spectroscopic analysis, including mass spectra and Nuclear Magnetic Resonance(NMR), and also comparison with reported data were used to elucidate the chemical structures of isolated compounds.Furthermore, all the isolated compounds were analyzed for 3-(4, 5-dimethylthiazol-2-yl)-5-diphenyltetrazoliumbromide -based cytotoxicity studies on human colon cancer cell lines, HT-29 and HCT-15; among all the testedcompounds, quercetin and odoratin-7-glucoside have shown a good cytotoxicity toward the selected cell lines.

Keywords

Bauhinia foveolata, 13-Docosenamide, flavonoids, cytotoxicity

Citation

Habbu Prasanna V., Miskin Narayan, Venkatrao H. Kulkarni, Bhat Pradeep, Joshi Arun, Bhandarkar Anant, Kulkarni Satish, Dixit Sheshagiri R., Vaijanathappa Jaishree. Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India. Journal of Applied Pharmaceutical Science. 2020 Mar; 2020 Mar: 135-148

URI

https://imsear.searo.who.int/handle/123456789/210718

Collections

Journal of Applied Pharmaceutical Science (JAPS)

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