Antimicrobial evaluation and molecular properties prediction of pyrazolines incorporating benzofuran and pyrazole moieties
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Date
2020-02
Journal Title
Journal ISSN
Volume Title
Publisher
Open Science Publishers LLP
Abstract
A series of chalcones 3–5, 1H-pyrazolines 6–8, N-phenylpyrazolines 9–11, and N-acetylpyrazolines 12–14incorporating benzofuran and pyrazole moieties were synthesized and screened for their in vitro antimicrobial activityagainst some of pathogenic microorganisms. Among the screened compounds, 7 and 13 showed the most promisingantibacterial activity against Escherichia coli (G-). Compound 11 displayed broad spectrum antibacterial activityagainst Bacillus subtilis (G+). Moreover, compounds 10 and 4 were found to be the most potent antifungal agentagainst Candida albicans and Aspergillus niger, respectively. Also, the molecular properties prediction and druglikeness model score (DLS) of all the synthesized compounds were calculated by SwissADME and MolSoft websites,respectively. The two compounds 7 and 13 were found to be maximum DLS of 0.75 and 0.83, respectively.
Description
Keywords
Pyrazoline, benzofuran, pyrazole, antimicrobial activities, drug-likeness, Lipinski rules.
Citation
Mervat A. Elsherif, Hassan Ashraf S., Moustafa Gaber O., Awad Hassan M., Morsy Nesrin M.. Antimicrobial evaluation and molecular properties prediction of pyrazolines incorporating benzofuran and pyrazole moieties. Journal of Applied Pharmaceutical Science. 2020 Feb; 2020 Feb: 037-043