Bioproduction of cytochalasin D by endophytic fungus Xylaria sp. DAP KRI-5
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Date
2019-04
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Publisher
Open Science Publishers LLP
Abstract
Recently, endophytic fungi have attracted attention due to their ability to produce a variety of bioactive metabolites. Inthe course of our study on endophytic fungi associated with Albertisia papuana Becc, it has been found the endophyticfungus Xylaria sp. DAP KRI-5 produce cytochalasin D. Isolation of cytochalasin D was conducted by using anopen column chromatography method. The chemical structure of cytochalasin D was deduced from 1 dimension, 2dimension nuclear magnetic resonance, and ultra-performance liquid chromatography quadrupole time of flight massspectrometry analyses and also compared with the published data. The bioproduction capacity of cytochalasin D bythe fungus Xylaria sp. DAP KRI-5 was 0.05763 g/l.
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Keywords
Isolation, characterization, bioproduction, cytochalasin D, endophytic fungus
Citation
Fathoni Ahmad, Agusta Andria. Bioproduction of cytochalasin D by endophytic fungus Xylaria sp. DAP KRI-5. Journal of Applied Pharmaceutical Science. 2019 Apr; 2019 Apr: 105-110