Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties
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Date
2019-07
Journal Title
Journal ISSN
Volume Title
Publisher
Open Science Publishers LLP
Abstract
Both resveratrol and pterostilbene are monomeric stilbenes having a 6−2−6 carbon skeleton with two phenyl ringslinked by a double-bonded ethylene bridge. Resveratrol has three hydroxyl (−OH) groups, while pterostilbene hastwo methoxy (–OCH3) groups and one −OH group. They commonly occur in the trans form rather than the cis form.Red grapes and red wines are the main dietary sources of the resveratrol. Pterostilbene occurs in blueberries andgrapes. Resveratrol and pterostilbene exhibit many similarities in pharmacological properties, including antioxidant,neuroprotective anti-cancer, cardioprotective, analgesic, anti-atherosclerosis, anti-aging, anti-diabetic, antiinflammatory, and anti-obesity activities. The stronger pharmacological properties in pterostilbene than resveratrolhave been attributed to its two –OCH3 groups. As a result, pterostilbene is more lipophilic which enhances itsmembrane permeability, bioavailability, and biological potency. Some future studies on resveratrol and pterostilbeneare suggested. The sources of information cited in this comparative overview were from Science Direct, GoogleScholar, and PubMed.
Description
Keywords
Resveratrol, pterostilbene, pharmacology, pharmacokinetics, future research.
Citation
Chan Eric Wei Chiang, Wong Chen Wai, Yong Hui Tan, Foo Jenny Pei Yan, Wong Siu Kuin, Chan Hung Tuck. Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties. Journal of Applied Pharmaceutical Science. 2019 Jul; 2019 Jul: 124-129