C-glycosyl flavonoids-rich extract of Dipcadi erythraeum Webb & Berthel. bulbs: Phytochemical and anticancer evaluations

Dipcadi erythraeum Webb & Berthel. is a wild edible species belonging to family Asparagaceae and commonlyused in folk medicine. The D. erythraeum bulbs extract was subjected to chemical investigation using LiquidChromatography-Electrospray Ionization Mass Spectrometry (LC-ESI-MS) technique to identify its polar activeconstituents and evaluated against four human carcinoma cell lines; MCF7, HEPG2, A549, and HCT116. The D.erythraeum bulbs extract revealed 22 phenolic compounds characterized for the first time from the studied species,14 of them were identified as C-glycosyl flavonoids. Moreover, the studied extract showed moderate activity againstMCF7 and HCT116 at 100 µg/ml with cell viability of 43.6% and 48.4%, respectively. From the chemotaxonomicpoint of view, the presence of C-glycosyl flavonoids supported that D. erythraeum has a closer relationship with thespecies of Asparagaceae family than Liliaceae.

Keywords

Dipcadi erythraeum, C-glycosyl flavonoids, LCESI-MS, cytotoxic activity

Citation

Marzouk Mona M., Elkhateeb Ahmed, Latif Rasha R. Abdel, Abdel-Hameed El-Sayed S., Kawashty Salwa A., Hussein Sameh R.. C-glycosyl flavonoids-rich extract of Dipcadi erythraeum Webb & Berthel. bulbs: Phytochemical and anticancer evaluations. Journal of Applied Pharmaceutical Science. 2019 Jun; 2019 Jun: 094-098

URI

https://imsear.searo.who.int/handle/123456789/210392

Collections

Journal of Applied Pharmaceutical Science (JAPS)

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