E-Cadherin as a Marker for Nodal Metastasis in Head and Neck Squamous Cell Carcinoma
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Date
2019-05
Journal Title
Journal ISSN
Volume Title
Publisher
SCIENCEDOMAIN international
Abstract
Aim: Head and neck cancers, all over the world, contribute greatly to the number of deaths, despite the advancements in the therapeutic strategies. It is characterized by locoregional disease with a tendency for metastasis to the cervical lymph nodes. The pre-operative detection of lymph node metastasis is critical for the effective treatment of patients with head and neck squamous cell carcinoma. Therefore the objective of this study was to identify E-cadherin as a marker for prediction of lymph node metastasis in head and neck squamous cell carcinoma (HNSCC).Study Design:Cross-sectional study.Place and Duration of Study: Dow University of Health Sciences, Karachi. 1 Year duration.Methodology:Cross-sectional analysis of 54 subjects with HNSCC, who underwent neck dissections, was carried out. Expression of E-cadherin was evaluated using immunohistochemical analysis and traditional histological parameters, and correlation of E-Cadherin with histologically verified presence of regional metastases was determined. Data was subjected to descriptive statistics and chi-square using Spss v.16.0.Results:54 patients included 33 males (61.1%) and 21 females (38.9%) aged from 18 to 73 (mean 44.8±12.7). A statistically significant relationship between the Downregulation of E-cadherin and histologically verified presence of nodal metastasis was established. (p value= 0.01).Conclusion:This study shows that low E-cadherin expression is useful for predicting lymph node metastases in cases of head and neck carcinoma.
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Keywords
E-cadherin, cancer, neoplasm, metastasis, lymph node
Citation
Butt Saima Akram, Ali Anwar, Avesi Lubna, Khan Shoaib, Mustansir Tazeen, Mirza Talat. E-Cadherin as a Marker for Nodal Metastasis in Head and Neck Squamous Cell Carcinoma. Journal of Advances in Medicine and Medical Research. 2019 May; 29(9): 1-9