Hematological Changes in HCV Patients Treated with Different Sofosbuvir-Based Regimens
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Date
2020-09
Journal Title
Journal ISSN
Volume Title
Publisher
SCIENCEDOMAIN international
Abstract
Introduction: Treatment of HCV with direct acting antiviral agents (DAAs) with the different regimen dramatically changed the outcomes of the disease beside its eradication. In the same time hematological concerns as anemia, thrombocytopenia, and leucopenia were a major factor before initiation, or during treatment with the antiviral drugs.Aim: To demonstrate hematological changes during and after treatment with different regimen of DAAs.Methods: Follow up the hematological changes before, during and after treatment for 100 patients with chronic HCV treated with five different sofosbuvir-based regimen; using interferon, ribavirin, simeprevir and daclatasvir.Results: There are no similar linear changes regarding anemia, leucopenia or thrombocytopenia, however, combination therapy using sofosbuvir with simeprevir or daclatasvir significantly increase platelets count, WBCs, and hemoglobin level during and after end of treatment, versus regimens uses sofosbuvir with ribavirin and or interferon that showed significantly decreased hematological values during and after treatment.Conclusion:Sofosbuvir-based regimen has favorable hematological changes in patients with chronic HCV infection during and after treatments especially with sofosbuvir and daclatasvir
Description
Keywords
DAAs, HCV, Hematological changes
Citation
Ahmed Abdel Khalek, Abdel Raouf El-Deib, Gamal Tawfik, Soliman Nashaat, Mosaad Mohamed. Hematological Changes in HCV Patients Treated with Different Sofosbuvir-Based Regimens. International Journal of TROPICAL DISEASE & Health. 2020 Sep; 41(12): 10-17