Expression of CK19, CD56, and Galectin-3 Tumor Markers in Different Types of Thyroid Carcinoma
Loading...
Date
2019-06
Journal Title
Journal ISSN
Volume Title
Publisher
Sumathi Publications
Abstract
Background: Thyroid disorders represent a major problem in Saudi Arabia, particularly in the northern part of the country. The objective of the current study was to investigate the immunohistochemical expression of CK19, CD56, and Gal-3 in a series of Saudi patients with thyroid carcinoma in Northern Saudi Arabia (Hail) region. Methodology: This is a retrospective study, investigated 50 formalin-fixed paraffin wax tissue blocks with a confirmed diagnosis of thyroid carcinoma from Northern Saudi Arabia. Immunohistochemistry demonstration was for CK19, CD56, and Gal-3 markers applying Avidin-Biotin method. Results: Out of the 50 patients, 45(90%) were females and 5(10%) were males, aged 13-70 years old with a mean age of 43 years. CK19 was positively expressed in 74% of the thyroid carcinoma. Positive CD56 expression was demonstrated in 45.7%, 58.3%, and 100% of the papillary, follicular and undifferentiated thyroid carcinomas, correspondingly. Positive Galectin-3 expression was demonstrated in 71.4%, 58.3%, and 100% of the papillary, follicular and undifferentiated thyroid carcinomas, correspondingly. Conclusion: Papillary thyroid carcinoma is the most common thyroid cancer in Northern Saudi Arabia. Females represent more than 90% of the cases of the thyroid carcinoma in Northern Saudi Arabia. CK19, CD56, and Gal-3 are useful for the assessment of thyroid carcinoma.
Description
Keywords
Thyroid cancer, Papillary carcinoma, Follicular carcinoma, Saudi Arabia, CK19, CD56, Gal-3
Citation
Alshammari Dina, Saadaldin Afra, Elasbali Abdelbaset Mohamed, D. Fawaz, Alshammri, Almansi Walid, Ahmed Hussain Gadelkarim. Expression of CK19, CD56, and Galectin-3 Tumor Markers in Different Types of Thyroid Carcinoma. International Journal of Medical Research & Health Sciences. 2019 Jun; 8(6): 125-134