Influence of Ozagrel Sodium along Atypical Anti-psychotic Drug on Red Blood Cell Distribution Width in Rats with Minimum and Maximum Dose Comparison
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Date
2019-06
Journal Title
Journal ISSN
Volume Title
Publisher
Sumathi Publications
Abstract
Objective: To study the activity of ozagrel sodium alone and in combination with the atypical antipsychotic drug on Red blood cell distribution width (RDW-CV) along with different doses and their comparison in rats. Method: This experimental study consisted of 120 albino rats of both gender, they were of 310-350 g, there were 10 groups which consists of each of 12 rats (n=12). Rats were treated with an accurate dose of ozagrel and atypical antipsychotic (Zuclopenthixol cis isomer of clopenthixol) alone and in combination for 3-weeks (21 days). We obtained blood sample at 0, 7th, 14th and last day of the study. Red blood distribution widths were measured from blood tests by utilizing standard medical laboratory technique. Red blood cell distribution width (RDW-CV) was measured by using the coefficient of variation indicator. Results were gathered and summarized by applying statistics. The comparison was formed between all days value to zero-day. Results: Minimum dose treated groups by both medications showed an increase and RDW-CV, but maximum dose showed p<0.001 decreases in RDW-CV in individual groups of drugs treatment and in case of RDW-CV maximum dose showed an increasing trend with p<0.001 in the combination groups. Conclusion: Maximum dose of ozagrel may cause a decrease in RDW-CV alone and it may cause an increase in (RDW-CV) with a combination of atypical antipsychotic drug.
Description
Keywords
Red blood cell, Width, Coefficient of variation, Ozagrel sodium, Atypical, Technique
Citation
Bashir Muhammad Irfan, Saleem Uzma, Anwer Fareeha, Ahmad Bashir. Influence of Ozagrel Sodium along Atypical Anti-psychotic Drug on Red Blood Cell Distribution Width in Rats with Minimum and Maximum Dose Comparison. International Journal of Medical Research & Health Sciences. 2019 Jun; 8(6): 109-113