Transient leukaemia of Down syndrome in a neonate: case report
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Date
2019-11
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Transient leukemia of Down syndrome(TL-DS)' or transient myeloproliferative disorder (TMD) or transient abnormal myelopoiesis (TAM) is a hematologic abnormality characterized by an uncontrolled proliferation of myeloblasts in peripheral blood and bone marrow which characteristically affects newborns and babies with Down syndrome. Children with Down syndrome (Trisomy 21) have a unique predisposition to develop myeloid leukemia of Down syndrome(ML-DS). In majority of cases of TL-DS, the GATA1 mutant clone goes into spontaneous remission without the need for chemotherapy. However, 10-20 % of neonates with TL-DS and silent TL-DS subsequently develop ML-DS in the first 5 years of life due to additional oncogenic mutations acquired by the persistent GATA1 mutant cells. We present here, one such case of Down syndrome with TL-DS in a neonate.
Description
Keywords
Down syndrome, neonate, Transient abnormal myelopoiesis, Transient leukaemia of Down syndrome, Transient myeloproliferative disorder, Tumor lysis syndrome
Citation
Bhaisara Baraturam, Korday Charusheela, Wade Minal, Chunchu Chandra Kiran, Modi Priyanka, Singh Dinesh Kumar. Transient leukaemia of Down syndrome in a neonate: case report. International Journal of Contemporary Pediatrics. 2019 Nov; 6(6): 2712-2715