A case of primary immunodeficiency: hyper IgM syndrome
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Date
2019-11
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Hyper IgM syndrome are group to disorders characterized by elevated serum level of IgM and low or absent serum levels of IgG, IgA and IgE the mechanism of HIGM is immunoglobulin Class-Switch Recombination (CSR) failure and Somatic Hyper Mutation (SHM). This diagnosis should be considered in any patient presenting with hypogammaglobulinemia, with low or absent IgG and IgA and normal or elevated IgM level. In the present case report, this was a 6-year-old male child who had history of recurrent respiratory tract infections who presented with otitis media and persistent fever spikes. Immunoglobulin studies revealed a pattern consistent with hyper IgM.
Description
Keywords
Citrobacter, Class-switch recombination, CSOM (Chronic Suppurative Otitis Media), HIGM (Hyper-IgM syndrome), IVIG (Intravenous Immunoglobulin), Tuberculosis
Citation
Fadnis Madhura P., Shamkuwar Pratibha B.. A case of primary immunodeficiency: hyper IgM syndrome. International Journal of Contemporary Pediatrics. 2019 Nov; 6(6): 2700-2701