Primary antiphospholipid syndrome in children: experience from two tertiary centres in South India
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Date
2019-03
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the presence of episodes of vascular thrombosis, recurrent fetal loss and other clinical features in the presence of antiphospholipid antibodies. The aim of the study was to analyze the clinical manifestations and immunologic profile of children presenting with APS.Methods: Authors did a retrospective case record study of patients admitted with thrombotic events between September 2013 and August 2018 and identified patients with positive antiphospholipid antibodies. Children who had clinical features of active lupus were not included.Results: The clinical and immunologic profile of 7 pediatric patients presenting with APS over 5 years from 2013 to 2018 were analysed. Symptoms secondary to vascular thrombosis were limb swelling, stroke, gangrene of toes and Budd Chiari syndrome.Conclusions:APS though rare should be considered in the differential diagnosis of children presenting with thrombotic events. They need long term anticoagulants to prevent further episodes.
Description
Keywords
Children, Primary antiphospholipid syndrome, Thrombosis
Citation
Janarthanan Mahesh, Jayaraman Dhaarani, Scott Julius, Latha M. S., Margabandhu Saravanan, Sundaramoorthy Chitra, Srinivas S.. Primary antiphospholipid syndrome in children: experience from two tertiary centres in South India. International Journal of Contemporary Pediatrics. 2019 Mar; 6(2): 243-247