Association of GLUT-1 (XbaI) Gene Polymorphism in Diabetes and Diabetes Nephropathy Patients of North Indian Population
Loading...
Date
2019-06
Journal Title
Journal ISSN
Volume Title
Publisher
Society for research and Development in Education
Abstract
Diabetic nephropathy (DN) is a chronic complication of both type 1 and type 2 diabetes. However, there is still inadequate understanding of the exact mechanism related to progressive diabetic renal disease. The GLUT-1 XbaI gene polymorphism in the glucose transporter has been suggested in the development of DN. However, its association with T2DM and DN is controversial and has not been established in different ethnic populations. To enhance the understanding of GLUT-1 XbaI gene polymorphism in the context of T2DM and DN. We investigated the possible genetic association of GLUT-1 XbaI polymorphism with T2DM and DN in North Indian population. 100 T2DM patients and 100 patients of DN with 100 healthy controls were included in the study. GLUT-1 XbaI polymorphism was determined by PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism). The obtained data showed no significant association between GLUT-1 XbaI gene polymorphism with T2DM and DN leading us to conclude that GLUT-1 XbaI gene polymorphism may not have major effects on T2DM and DN in North Indian population.
Description
Keywords
Diabetic nephropathy, Gene polymorphism, Glucose transporter gene, Restriction fragment length polymorphism, Type 2 Diabetes melitus
Citation
Tiwari Sanchit, Alam Roshan, Ahmad Israr, Singh Seema, Sonkar Satyendra Kumar, Gyanendra Kumar Sonkar, Mohammad Kaleem Ahmad. Association of GLUT-1 (XbaI) Gene Polymorphism in Diabetes and Diabetes Nephropathy Patients of North Indian Population. International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL). 2019 Jun; 8(3): 1-6