Tumor Necrosis Factor-alpha (-308 G/A) is a Predictor for Development of Gestational Diabetes Mellitus in Saudi Pregnant Women

Inflammation may play a role in the pathogenesis of gestational diabetes mellitus (GDM) and also, it is one of the mostpopular pregnancy complications. The goal of the research was to study the association exists among common many formsin the stimulate area (-308G/A) of the TNF-alpha gene and increased danger for become better of GDM in Saudi pregnantwomen population.GDM and healthy subjects were genotyped with PCR- RFLP technique. No association was noticedamong the TNF-α -308 G/A in different and sensitivity to GDM disease in our Saudi cohort. There was a secondarycombination among TNF-α –308 G/A polymorphism in GDM (vs. normal control) (p = 0.605), which its triviality may becaused to survivor agent. The frequency of the -308 A allele (5) and genotype classification was in Hardy-Weinbergequilibrium (GG, n=54; GA, n=41; AA, n=5).The G-308A various, detected by PCR amplification and Nco-1 digestion,determines the lowest of a restriction site finding in a single band of 107 bp (the (A) allele). The (A) allele frequencies of the-308 (G/A) TNFα polymorphism were 26% in the GDM group and 29% in the depend subjects, with no significant differenceamong the two groups may be due to considerable variance in allele frequencies of the polymorphism by BMI quartiles (≥25kg/m2, for each quartile n=86) with -308G allele transporters had contains a higher BMI than A allele transporters(P=0.000**). Furthermore, considerable was found positively correlated with BMI, age, and children number.CONCLUSION: It could concluded that theTNF-α-308 G>A genotype frequency comparison among patients and controlwas not statistically significant in the Saudi women and also, the SNP in situation -308 (G/A) for the human. TNF- gene is adependent danger agent or a predictor for GDM.

Keywords

Tumor Necrosis Factor-alpha, -308TNF-α promoter, polymorphism, Saudi women

Citation

Qusti Safaa Y., Linjawi Sabah, Bakhashab Sherin, Alghamdi Aljohara, Balgoon Maha, Alotaibi Najat A., Qusty Naeem. Tumor Necrosis Factor-alpha (-308 G/A) is a Predictor for Development of Gestational Diabetes Mellitus in Saudi Pregnant Women. International Journal of Medical Research Professionals. 2019 Jan; 8(1): 213-223

URI

https://imsear.searo.who.int/handle/123456789/203613

Collections

International Journal of Pharmaceutical Research and Allied Sciences

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