Osteoprotegerin Levels among Saudi Cardiovascular Patients
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Date
2019-01
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Pharmaceutical Research and Allied Sciences
Abstract
Background: Cardiovascular Diseases (CVD) are considered an overwhelming health burden in Saudi Arabia, greatlyaggravated with the increasing rates of Diabetes Mellitus (DM) and obesity. Osteoprotegerin (OPG) is one of the tumornecrosis factor receptors, commonly associated with coronary heart diseases. This study examines the possible correlationamong OPG with both DM and CVD. Methods: The study was conducted in Jeddah, Saudi Arabia and included 201subjects. They were divided into four matched groups: group 1 were patients with CVD only; group 2 were patients with DMtype 2; group 3 were patients suffering from DM and CVD, and group 4 was normal control. All groups were divided intomale and female subgroups. The following parameters were measured; complete blood picture, lipid profile, insulin, fastingglucose and kidney function and also then relationship to OPG levels. Results: OPG was significantly elevated in males withCVD alone (8.31 ± 4.01 ng/ml), or in association with DM (6.54 ± 3.55 ng/ml). An increase was noted in female patients,but only in the DM and CVD groups (6.75 ± 3.3 ng/ml). A weak positive correlation was detected between OPGconcentrations with both fibrinogen and glucose levels in females, while in males OPG levels were positively correlated withwaist to hip ratios. Conclusion: OPG could be a valuable biomarker for early CVD appearance.
Description
Keywords
Cardiovascular Diseases, Osteoprotegerin, Obesity, Lipid Profile.
Citation
Khalid Zaki Al-Shali, Mohamed Nabil Alama, Mohammed Ali Ajabnoor, Fayeza F. Al-Fayaz, Khadija H. Balubaid. Osteoprotegerin Levels among Saudi Cardiovascular Patients. International Journal of Medical Research Professionals. 2019 Jan; 8(1): 95-101