Comparative Evaluation of Efficacy and Safety of BepotastineBesilate versus Olopatadine and Ketorolac Combination in Patients with Vernal Keratoconjunctivitis
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Date
2019-07
Journal Title
Journal ISSN
Volume Title
Publisher
Ibn Sina Academy of Medieval Medicine & Sciences
Abstract
Objective: Comparative evaluation of efficacy and safety ofBepotastine besilate versus Olopatadine and Ketorolaccombination in patients with vernal keratoconjunctivitis.Materials and Methods: This was a prospective, open label,randomized, comparative clinical study. Hundred patients ofvernal keratoconjunctivitis between 6 to 20 years of age ofeither sex willing to give informed consent were enrolled in thestudy. In Group 1, 50 patients received Bepotastine besilate(0.15%) eye drops twice daily for 8 weeks whereas in Group 2,50 patients received Olopatadine (0.2%) and Ketorolac (0.4%)combination eye drops twice daily for 8 weeks. Symptoms andsigns scoring of VKC were recorded on baseline and at thetime of follow up at 4 and 8 weeks. Safety assessments werealso done in both the drug groups during the study period forany serious adverse effects.Results: After the 2 months of drug therapy, patients in boththe groups showed improvement in the symptoms and signsscoring of VKC. However, there was no statistically significantdifference between the two treatment groups at 4th and 8thweek. Both the drugs were well tolerated without any seriousadverse effect.Conclusion: Both bepotastine besilate versus olopatadine andKetorolac combination ophthalmic solutions were found to beeffective in alleviating the clinical symptoms and signs of VKC.
Description
Keywords
Mast Cell Stabilizer, Topical NSAIDs, Newer H1-antihistaminics, SAEs, Vernal Keratoconjunctivitis
Citation
Sharma Vivek, Dahiya Jyoti, Sachdeva Sumit, Gupta MC, Sharma Shalini. Comparative Evaluation of Efficacy and Safety of BepotastineBesilate versus Olopatadine and Ketorolac Combination in Patients with Vernal Keratoconjunctivitis. International Journal of Medical Research Professionals. 2019 Jul; 5(4): 1-6