Helicobacter Pylori Sequential Eradication Therapy: Clarithromycin based Therapy Versus Levofloxacin based Therapy. Study from Kashmir Valley

Introduction: Various regimens have been used for H-pylorieradication. Sequential therapy is an alternative to classicaltriple therapy. This study was designed for evaluatingthe efficacy of levofloxacin based sequential therapyvs clarithromycin based sequential therapy in H-pylorieradication.Material and methods: It is a randomized clinical trial. Twohundred H. Pylori infected patients diagnosed by rapid ureasetest (RUT) on UGI endoscopy were randomly divided intotwo groups A and B. Group B Levofloxacin based sequentialregimen and group A clarithromycin based sequential regimen.H-pylori eradication status was evaluated with rapid ureasetest on UGI endoscopy 6 weeks after completion of sequentialtherapy.Results: As per protocol, eradication rates for group B and Awere 86% and 81% respectively. Eradication rate for H-pyloriis greater with levofloxacin based sequential therapy ascompared to that of clarithromycin based sequential therapybut it is not statistically significant p >0.05.Conclusion: Levofloxacin based sequential therapy has highereradication rate than clarithromycin based sequential therapy.Although not statistically significant in our study, levofloxacinbased sequential therapy could be better alternative forthe treatment of H-pylori in areas with high clarithromycinresistance.

Keywords

H-pylori, Levofloxacin, Clarithromycin, Sequential Therapy

Citation

Mir M Muzzafer, Mir Intikhab M, Taranum Ursilla M, Muzzafar M Hakeem, Wani Zeeshan A, Mir Bilal. Comparative Study of Carrying Angle between Dominant and Non Dominanat Limb in Kashmiri Population. International Journal of Contemporary Medical Research . 2019 Jun; 6(6): f1-f4

URI

https://imsear.searo.who.int/handle/123456789/202331

Collections

International Journal of Contemporary Medical Research

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