Clinical pharmacological studies on centpropazine--a new antidepressant compound.

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Date
1989-10-01
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Abstract
Single oral doses of 10 to 160 mg centpropazine, a new antidepressant (synthesized by CDRI, Lucknow, India) were administered to groups of 4-5 male volunteers, each dose being interspersed with placebo in a double blind, non-crossover study by random distribution. The drug was well tolerated. Drowsiness, heaviness, weakness and/or headache were reported only at doses of 120 mg and above. No adverse effect was noted in various laboratory tests, ECG or vital parameters. In a multiple dose study, volunteers received 40 or 80 mg centpropazine daily for 4 wk. Mild restlessness and insomnia were observed in some subjects receiving 80 mg dose. In this study also no effect was observed in various laboratory tests, ECG or vital parameters.
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Gupta PP, Asthana OP, Tangri AN, Dhawan BN. Clinical pharmacological studies on centpropazine--a new antidepressant compound. Indian Journal of Medical Research. 1989 Oct; 90(): 360-2
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https://imsear.searo.who.int/handle/123456789/20119
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Indian Journal of Medical Research