Pseudocholinesterase As A Predictor Marker In Hypothyroid Patients
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Date
2018-07
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Publisher
Sumathi Publications
Abstract
Introduction: Hypothyroidism is due to decreased circulating levels of Thyroid hormones and is caused by inade-quate functioning of thyroid gland. Pseudocholinesterase (PCHE) is a nonspecific cholinesterase enzyme that hydro-lyses choline based esters in plasma. The purpose of this study was to evaluate the serum level of PCHE in hypothy-roid patients. Methodology:The present study was conducted on 100 newly diagnosed hypothyroid patients attend-ing the Medical OPD. The results of patients were compared with 100 healthy controls of either sex of similar age group. Anthropometric measurements, T3, T4, TSH, PCHE & Cholesterol estimations were performed. Results:The mean serum PCHE (decrease) level was observed statistically highly significant (p<0.001) in hypothyroid patients as compared with healthy control subjects. A highly significant positive correlation between PCHE with T3 & T4 (p< 0.001) in hypothyroid cases. Conclusion:Serum Pseudocholinesterase may be helpful as biomarker in screening test for hypothyroidism along with thyroid stimulating hormone.
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Keywords
Hypothyroidism, Thyroid Profile, Pseudocholinesterase
Citation
Kaushik GG, Soni Reena . Pseudocholinesterase As A Predictor Marker In Hypothyroid Patients . International Journal of Clinical and Biomedical Research. 2018 Jul; 4(3): 27-29