Pharmacokinetics of cefquinome in goats after intramuscular administration alone and with meloxicam
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Date
2020-04
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Background: Nonsteroidal anti-inflammatory drugs and antibiotics are commonly prescribed together. We aimed to study the kinetic profile of cefquinome (2 mg/kg b.wt.) following intramuscular administration of it alone and co-administered with meloxicam (0.2 mg/kg b.wt.) in goats.Methods: Five Egyptian Baladi goats, each goat was injected intramuscularly at the dose rate of 2 mg/kg b.wt. Cefquinome into the deep gluteal muscle of hindquarter alone and then after fifteen days washout period, these animals also injected intramuscularly at the dose rate of 2 mg/kg b.wt. Cefquinome preceded with meloxicam at the dose rate of 0.2 mg/kg b.wt. The serum concentrations of cefquinome were detected by high performance liquid chromatography, two compartment model.Results: Following a single dose intramuscular administration of cefquinome alone, peak plasma concentration (1.71�0189 ?g/ml) was obtained at 1.59�0038 h. The absorption half-life (t1/2ab), total body clearance (Cltot), elimination half-life (t1/2el) and area under curve (area under concentration (AUC(0-inf)) of cefquinome were 0.4�0028 h, 0.068�78 l/h/kg, 9.21�178h and 29.36�78 礸.h.ml-1, respectively. Following a single dose intramuscular co-administration of cefquinome and meloxicam, peak plasma concentration (1.60�0124 ?g/ml) was obtained at 1.49�0092 h. The absorption half-life (t1/2ab), total body clearance (Cltot), elimination half-life (t1/2el) and area under curve (AUC(0-inf)) of cefquinome were 0.396�006 h, 0.094�25 l/h/kg, 6.5�221 h and 21.38�696 礸/h/ml, respectively. Non significant alters were reported in the parameters following co-administration of Cefquinome with meloxicam.Conclusions: From our results, may be concluded that intramuscular administration of meloxicam may be successfully co-administrated with cefquinome for combating bacterial infections with an inflammatory condition in goats without any antagonistic effect.
Description
Keywords
Kinetic, Cefquinome, Meloxicam, Intramuscular, Goats
Citation
El Hanbally Saber, El Gendy Hanem, El Gendy Hanem, El Hewaity Mohamed, El Hewaity Mohamed. Pharmacokinetics of cefquinome in goats after intramuscular administration alone and with meloxicam. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 518-522