Cefixime induce non convulsive status epileptics: a neurotoxic effect
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Date
2019-10
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Nonconvulsive status epileptics comprises a group of syndromes that display a great diversity regarding response to anticonvulsants ranging from virtually self-limiting variants to entirely refractory forms cephalosporins are thought to provoke seizure through inhibitory effects on gamma-aminobutyric acid (GABA) transmission and GABA receptors. Interference with GABA transmission result in pre-disposition towards excitatory neurotransmission, which can leads to seizures. Antibiotics can alter the serum concentration of anti-epileptic, resulting in seizures and anti-epileptic drugs toxicity.
Description
Keywords
Cephalosporin and seizure, Neurotoxicity and seizure, Antiepileptic drugs
Citation
Bhardwaj Ankit, Sharma Atma Ram, Sharma Sarla. Cefixime induce non convulsive status epileptics: a neurotoxic effect. International Journal of Basic & Clinical Pharmacology. 2019 Oct; 8(10): 2341-2343