Anti-tumor effect of fruit rind of Myristica malabarica in an Ehrlich ascites carcinoma model
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Date
2019-03
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Background: Among the various modalities of anti-cancer treatment, cancer chemotherapy plays a very vital role. The alarming side effects being its main drawback leads to relentless research for newer agents. A new natural agent with promising anti-cancer properties from in-vitro studies leads to this study. Here we have evaluated the anti-tumor activity of a crude extract of fruit rind of Myristica malabarica in an Ehrlich ascites carcinoma model in mice.Methods: A murine model of cancer was established with i.p. inoculation of Ehrlich Ascites carcinoma (EAC) cells; animals were divided into five groups (including normal control) to observe the inhibitory effect of a crude extract of the fruit rind of Myristica malabarica/rampatri (0-100mg/kg b.w. i.p.) as compared with methotrexate (0.4mg/kg bw., i.p.). Blood and ascitic fluid were collected on the 10th day for analysis.Results: In the EAC model, there was an increase in tumor volume, tumor weight, and tumor packed cell volume, which was decreased by rampatri (50 and 100mg/kg bw) along with an increase in the mean survival time (MST). Rampatri caused minimal alterations in hematological parameters, renal functions remained unchanged but an increase in hepatic SGOT was demonstrated.Conclusions: The crude extract of rampatri (containing Malabaricones) exhibited significant anti-tumor activity with minimal effect on hematological and renal functions.
Description
Keywords
Anti-tumor, Ehrlich ascites carcinoma, Malabaricones, Myristica malabarica, Rampatri
Citation
Bandyopadhyay Chandrakana, Manna Alak, De Soumita, Yasmin Nafisha, Bauri Ajay K., Chattopadhyay Subrata, Chatterjee Mitali. Anti-tumor effect of fruit rind of Myristica malabarica in an Ehrlich ascites carcinoma model. International Journal of Basic & Clinical Pharmacology. 2019 Mar; 8(3): 383-387