Clonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscience
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Date
2018-12
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
The alpha-2 adrenergic receptor (?-2 AR) agonists have a long history of use in treating different clinical conditions, such as hypertension, psychiatric entities (e.g., attention-deficit hyperactivity disorder), chronic pain, panic disorders, and, lately, for treating opioid withdrawal syndrome. In recent years, ?-2 AR medications have been administered as adjuncts for managing inflammatory conditions, depression, chronic pain, sleep and cognitive disorders. This review will provide some clinical applications in neuroscience for this class of drugs. Understanding the pharmacological mechanisms is essential to obtaining neurochemical data that demonstrate that ?-2 AR agonists have potential clinical significance in neuroscience.
Description
Keywords
?-2 AR agonists, Cognitive, Depression, Immune system, Pain, Sleep
Citation
Eldufani Jabril B., Elahmer Nyruz R., Nekoui Alireza, Blaise Gilbert A.. Clonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscience. International Journal of Basic & Clinical Pharmacology. 2018 Dec; 7(12): 2476-2482