Immunosuppressant effect of Boswellia serrata extract on CFA induced arthritis in rats
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Date
2018-10
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Background: Rheumatoid arthritis (RA) is an immune-mediated arthropathy, so for the treatment disease modifying antirheumatoid drugs are required. In this study we are evaluating the immunomodulatory property of Boswellia serrata extract (BSE) as an alternative medicine.Methods: Complete Freund’s adjuvant (CFA), 0.1ml was injected intradermally in the footpad of left hind paw in 36 Wistar rats to induce RA. Animals were divided into 6 groups. BSE in the doses of 45mg/kg, 90mg/kg and 180mg/kg was administered and cyclophosphamide as standard drug. Various parameters as body weight, paw thickness, ankle diameter, paw volume, arthritis index, TNF- ? and histopathological changes were analyzed.Results: Marked reduction in paw thickness, ankle diameter, paw volume, arthritis index and an improved body weight was found in high dose BSE (180mg/kg) group but the effect was lesser than standard drug Cyclophosphamide.Conclusions: BSE has significant potential as an alternative medicine for treatment of autoimmune diseases like rheumatoid arthritis.
Description
Keywords
Boswellia serrata extract, Complete Freund’s adjuvant, Cyclophosphamide, Rheumatoid arthritis
Citation
Singh Sarvesh, Kumar Rajendra, Saksena Anil Kumar, Pal Rishi, Jaiswal Riddhi, Kumar Rahul. Immunosuppressant effect of Boswellia serrata extract on CFA induced arthritis in rats. International Journal of Basic & Clinical Pharmacology. 2018 Oct; 7(10): 1921-1928