Evaluation of antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino wistar rats
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Date
2018-07
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Publisher
Medip Academy
Abstract
Background: The objective was to evaluate the antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino rats in comparison with a currently used oral hypoglycaemic glibenclamide.Methods: there were 24 rats with FBS in the range 80-115 mg/dl were selected for the study. Four groups each containing six rats, were induced diabetes with alloxan (150mg/kg). The diabetic control group (0.5ml normal saline), Standard control group (5mg/kg glibenclimide), Test group I (200mg/kg T. cardifolia) and test II group 400mg/kg T. cardifolia). FBS was recorded on 1, 3, 7, 14, 21 and 28th day using glucometer. Data was analysed by using one way ANOVA and posthoc Tukey’s test SPSS 21Version.Results: Extract of Tinospora cardifolia showed dependent hypoglycaemic action in both low dose (200mg/kg) and high dose group (400mg/kg). Hypoglycaemic action with high dose of Tinospora cardifolia is comparable to that of standard drug glibenclamide.Conclusions: This study demonstrates the hypoglycaemic action of T. cardifolia in diabetic rats. T. cardifolia can be a therapeutic potential to treat type 2 diabetes mellitus.
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Keywords
Alloxan, Glibenclamide, Hypoglycaemia, Tinospora cardifolia
Citation
L. M. Abhijith, Sori Ravi K.. Evaluation of antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino wistar rats. International Journal of Basic & Clinical Pharmacology. 2018 Jul; 7(7): 1382-1386