Wheezing in Preschool Children and Total IgE Levels: A Birth Cohort Study
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Date
2020-03
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Pediatrics
Abstract
Objectives: To evaluate association between total IgE levels and wheezing in preschoolchildren from India. Methods: Datawere collected in a prospective birth cohort study relatedto wheezing till three years of age. Total IgE was measured at enrolment, at one year and twoyears of age and correlated with wheezing episodes. Results: A total of310 (167 boys)children were enrolled. Total IgE levels increased with age (P<0.001). Overall, 101 (32.6%)children had 182 episodes of wheezing. The median (IQR) total IgE levels in children withwheezing and without wheezing were similar at one year [42.1 (12.7, 93.5) vs 41.9 (17.1,96.7) kU/L; P=0.39] and two years of age [62.8 (32.4, 212.0) vs 75 (25.8, 173.0) kU/L,P=0.92). Conclusion: Total IgE levels increased with age and were not different in preschoolchildren with and without wheezing.
Description
Keywords
Immunoglobin E, Rhonchi, Under-five wheezer
Citation
Jat Kana Ram, Kumar Prawin, Mukherjee Aparna, Shivani Randev, Bipin Jose, M Kalaivani, Lodha Rakesh, Kabra Sushil K. Wheezing in Preschool Children and Total IgE Levels: A Birth Cohort Study. Indian Pediatrics. 2020 Mar; 57(3): 235-238